March 14, 2006 (Atlanta) — Stopping cholesterol-lowering statin drugs after long-term use packs not one, but two potentially dangerous punches to the heart.

That’s the bottom line of a new think about that shows that individuals who ceased taking the drugs experienced quick rises in both C-reactive protein (CRP) and LDL cholesterol levels. These data provide back for the acute increase in cardiovascular chance related with statin discontinuation, they compose.

Statins lower not as it were cholesterol, but too reduce CRP, a marker of hurtful aggravation in the supply routes that can lead to blood clots, says analyst Folkert Asselbergs, MD, PhD, of the University Medical Center Groningen in the Netherlands.

Dozens of thinks about have now shown that CRP, like cholesterol, is an critical, free predictor of heart attack and stroke hazard, he says.

“If you halt statins, it’s a double whammy,” Asselbergs tells WebMD. “Statin withdrawal leads to a quick and significant increase in CRP, independent of the parallel LDL increment.

“On the off chance that you’re on a statin, keep on your medicine!” he says.

Findings a Wake-Up Call

Asselbergs and colleagues studied 566 people who had been enrolled in a study setting the cholesterol-lowering statin sedate Pravachol against fake treatment.

Four years into the ponder those on Pravachol had:a 16% drop in CRP a 27% decrease in LDL “awful” cholesterol levels

In contrast, those on placebo had:a 4% increment in CRP Stable levels of LDL “awful” cholesterol

But when the participants on pravastatin ceased their medicine, both CRP and LDL “terrible” cholesterol shot up to pretreatment levels.

James H. Stein, MD, co-chairman of the cardiology meeting and associate teacher of medication at the College of Wisconsin Medical School in Madison, says the discoveries are a wake-up call.

“I can’t tell you how numerous people say they feel superior and want to halt their medication,” he tells WebMD.

“While it might seem like common sense merely would get more awful on the off chance that you are doing that, many people don’t accept it,” Stein says. “A think about like this appears us the size of how awful things can really get.”

Stein moderated a news conference to release the discoveries at the annual assembly of the American College of Cardiology.

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