Sept. 1, 2005 — An antiseizure drug called Neurontin may help ease hot flashes in women with breast cancer, analysts report within the Lancet.

Neurontin is affirmed to treat epilepsy. It has been studied before as an alternative to hormone replacement therapy for postmenopausal women who have hot flashes.

Hormone substitution therapy is indicated for treating menopausal symptoms like hot flashes, but for some women, such as those with breast cancer, HRT is not an alternative.

“We believe that [Neurontin] can be included to the list of non-hormonal specialists for the control of hot flashes in women with breast cancer,” write Kishan Pandya, MD, and colleagues. Pandya works at the College of Rochester Cancer Center.

Neurontin appeared benefits against hot flashes in postmenopausal ladies in an prior College of Rochester ponder.

Latest Study

Within the new study, analysts gave Neurontin or a fake medicate (fake treatment) to 420 ladies with breast cancer. The women were 55 a long time ancient, on normal; most were white. They were having at least two hot flashes per day at the study’s start.

The ladies were arbitrarily given a fake treatment, 300 day by day milligrams of Neurontin, or 900 daily milligrams of Neurontin for eight weeks. Higher doses (3,000-3,600 milligrams per day) are as a rule utilized to treat seizures.

No one knew which medicate they were taking.

The women were asked to keep journals detailing their hot flashes amid the ponder. About 350 did so all through the study.

Fewer, Less Severe Hot Flashes

The women’s diaries appear a 44% drop in hot streak recurrence and a 46% drop in hot streak seriousness scores after taking 900 milligrams of Neurontin for eight weeks.

The fake treatment and lower dosage of Neurontin didn’t essentially ease hot flashes. “The impacts of measurements higher than 900 mg/day merit advance consider,” type in the researchers.

It’s not clear how Neurontin helped soothe hot flashes, they note. Seizures aren’t a side effect of hot flashes.

Long-Term Utilize?

The ponder was brief, so the scientists can’t comment on long-term Neurontin utilize for hot flashes.

However, they write that the medicate “is used for long lengths for various other indications and certainly may well be considered for hot flashes also.”

Side Effects

Neurontin’s side impacts can include weariness or laziness, discombobulation or discombobulation (especially in the to begin with few weeks), swelling of the hands or feet, and hasty.

In Pandya’s study, the drug’s prompt side impacts weren’t famous, but women’s reasons for quitting the study early were recorded.

A few women said they quit because whatever medicate they were taking didn’t help; others cited side effects. Withdrawal rates were comparative for all three treatment bunches, compose the researchers.

Ladies encountering bothersome impacts of menopause, including hot flashes, ought to consult health care professionals almost their choices.

The North American Menopause society moreover makes the taking after recommendations approximately lifestyle: Less physical action increases the chance of hot flashes whereas every day exercise has been associated with an by and large decreased rate of hot flashes. Dodging hot and zesty nourishments; these have been detailed in some women to trigger hot flashes in spite of the fact that studies have not backed this. Cigarette smoking moreover has been associated with increasing the risk of hot flashes since it increments the breakdown of the hormone estrogen. Moderate, deep breathing. Relaxing activities.

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