Jan. 2, 2008 — New inquire about appears that the genetic roots of Down syndrome may secure against cancer.

The finding may lead to the creation of new cancer drugs, researcher Roger H. Reeves, PhD, a professor at Johns Hopkins College School of Medication, tells WebMD.

Such drugs are a long way off, but “individuals with Down disorder have now given us all the possibility of bringing down the incidence of cancer in everyone,” says Reeves.

That plausibility lies in the DNA of Down syndrome, Reeves’ group reports in tomorrow’s version of Nature.

Individuals with Down disorder have three copies of chromosome 21. Individuals without Down disorder have two copies of that chromosome. A few past thinks about have shown that cancer is rarer in people with Down syndrome, but not all ponders have come to that conclusion.

To learn more around the interface between cancer and Down disorder, Reeve and colleagues considered mice with qualities that make them likely to create intestinal cancer. A few of the mice also had a third chromosome that gave them a condition similar to Down syndrome.

The mice with the additional chromosome were less likely to create intestinal cancer and had littler tumors than the other mice.

A gene called Ets2 -may get the credit for that design. That gene sits on chromosome 21, so Down disorder provides an extra duplicate of the Ets2 quality — which abundance may curb cancer, Reeves notes.

He points out that the Ets2 gene had been suspected of causing — not checking — cancer. But in Down syndrome, the extra duplicate of that quality may tip the adjust in favor of cancer anticipation.

“This is often a new kind of quality which, in the event that you overexpress it, curbs tumor arrangement,” says Reeves.

“In case there were no such thing as Down disorder, we likely wouldn’t have found this since it wouldn’t make a lot of sense to take these oncogenes that we thought were genes that cause cancer and try to precise them at tall levels to try to prevent cancer. But that’s what happens” in their try, says Reeves.

He cautions that further considers are needed to see on the off chance that that’s true of other cancers, apart from the intestinal cancer his group studied in mice.

Reeves says he and his colleagues want to develop a potential sedate that would boost Ets2 in individuals without Down disorder to curb cancer.

It will take more work to see in case that can be done safely, but the think about “offers an explanation for why having three, instead of the normal two, duplicates of chromosome 21, the trademark of Down disorder in humans, gives some assurance from solid tumors,” composes David Threadgill, PhD, in a commentary distributed with the ponder.

Threadgill is an relate teacher of genetics at the University of North Carolina at Chapel Slope.

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